I really love this program. It was really easy to grasp, and it doesn't hog memory like Photoshop. (While it may sometimes be a little intense with processor use, it's not much of a problem.) I have never had a problem with lag or pen delay because of ComicWorks. CWX format has been a godsend for me -- the fact that I can have a file in 600DPI with 10+ layers and see it just approaching 2mb in filesize is nice.

Compared with Manga Studio, it's a good program, and fairly speedy. From a Mac perspective, it isn't so much better than Manga Studio that it's worth rebooting through Boot Camp to use it. The velocity from a digital pad and the pen window are better than Manga Studio. Other than that, Manga Studio Debut 4 is enough to get things done. I should mention that from a Windows perspective, Manga Studio debut uses twice as much memory as the Mac version... making Comicworks 5 times more efficient with memory in windows, but not so in OS X.